For the scientific background on MOTS-c and mitochondrial-derived peptides more broadly, see What Is MOTS-c
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For instance, -glucan-based formulations have been shown to prime mitochondrial metabolism and NLRP3 activation in macrophages, improving vaccine efficacy while maintaining immune balance (Qin et al., 2023)
Regardless of the method used, the results were equivalent in magnitude and statistically significant