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These results, presented today at the 2026 Scientific Sessions of the American Diabetes Association (ADA) and simultaneously published in The Lancet , mark an important step in building AstraZenecas differentiated weight management portfolio of monotherapies and combinations, supported by the Company's broad CVRM pipeline and global commercial expertise

Additionally, oxidative stress promotes Nrf2 recruitment to the PPARG promoter, activating PPARG, inducing adipogenesis, and accelerating NAFLD progression (Zhong et al., 2022)

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