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In another study, 45 patients with poorly controlled type 2 diabetes (mean HbA1c, 8.4%) were randomized to canagliflozin, liraglutide, or both on top of their existing treatment regimen [14], and -cell glucose sensitivity was calculated by a mathematical model using data from oral glucose tolerance tests with frequent sampling for insulin and C-peptide

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Hino K, Nagane M, Fujioka Y and Shiokawa Y

Estradiol dynamics during weight loss in women treated with GLP-1 receptor agonists

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