side effects of tirzepatide and semaglutide Comparative safety and tirzepatide: Implications for clinical decision-making in obesity management Tirzepatide vs. Semaglutide: What You

[2] Your mental health has gotten worse In some cases, semaglutide can cause changes in mood, including symptoms of anxiety and depression

providers to ensure care that is safe, effective, and personalized to your needs

These appointments allow for: Dose adjustments based on response and tolerability Assessment of treatment adherence Monitoring for emerging side effects or complications Evaluation of overall health improvements Discussion of lifestyle modifications supporting both treatments Never discontinue either medication abruptly without medical guidance, as this may cause withdrawal symptoms or symptom recurrence

People with kidney, heart, or liver disease should establish a safe daily fluid target with their physician, since both dehydration and fluid overload carry risks in these populations

CMS has introduced the BALANCE model demonstration program allowing states to expand GLP-1 coverage through negotiated manufacturer pricing starting May 2026, though participation is voluntary