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12 Neurobiological changes are evident in the premonitory stage and include alterations in nociceptive signalling, while the headache phase involves activation of the trigeminovascular system and, in migraine with aura, a cortical spreading depression-like event characterised by an electrophysiological wave of excitation followed by inhibition in cortical neurons
Patients may receive similar medications but encounter very different expectations, access pathways, and treatment experiences
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The findings also demonstrate the value of poison center data as a tool for near real-time assessment of emerging post-marketing drug trends
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