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Of the 75% who report digestive side effects, symptoms extend well beyond the nausea most commonly discussed in coverage of these medications, underscoring why a one-size-fits-all approach falls short and personalized care matters: 32% nausea 26% constipation 25% bloating or gas 21% acid reflux 21% feeling uncomfortably full after eating very little 21% diarrhea 18% abdominal pain 14% loss of appetite to the point of concern 10% vomiting From Trade-Off to Solution These findings land as GLP-1 use accelerates

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Figure 1 GLP-1 Receptors in the Kidney The distribution of GLP-1R in the kidney is controversial

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As GLP-1s become more socially acceptable, theres growing worry about misuse by people who dont meet clinical criteria for the medication