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Snyder concludes

Pre-filled pens should never be warmed in hot water or microwaves, as this can denature the peptide structure

Eur J Pharm Biopharm 177:5060 Beig A, Ackermann R, Wang Y, Schutzman R, Schwendeman SP (2022) Minimizing the initial burst of octreotide acetate from glucose star PLGA microspheres prepared by the solvent evaporation method