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5.4 Gaps in current knowledge and future directions While genomic plasticity contributes to resistance, the precise evolutionary trajectory of resistant Leishmania strains under drug pressure remains unclear, necessitating longitudinal studies to track genomic changes in response to treatment (Santi and Murta, 2022)

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PubMed: 37351564 TRIUMPH 1: Retatrutide versus Placebo in Obesity (Phase 3) human rct Jastreboff AM, Aroda VR, Bray GA, et al

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