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GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss

This approach allows any initial side effects to peak during the weekend when they have more flexibility to rest and hydrate at home

Skin rash or itching without other signs of an allergic reaction

However, their use is not without adverse effects, particularly gastrointestinal disturbances, which can impact treatment adherence and patient satisfaction [6]

However, the TRIUMPH-1 Phase 3 trial results indicated significant weight loss, with participants losing up to 28.3% of their body weight at 80 weeks