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To overcome these barriers, strategies include functionalizing NPs with BBB-targeting ligands (e.g., transferrin, ApoE-mimetics, mannose-integrated or dual-peptide systems) to enable receptor-mediated transport across the BBB
Yeswhen properly prescribed and monitored
Very recently, one agonist with sustained release (PB1046) has undergone further development for pulmonary hypertension [123]
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