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Lee: GLP-1 agonists primarily affect the gastrointestinal system, but they also act on the brain, particularly the hypothalamus, which regulates many core functions, including hormones, temperature, and appetite
PubMed Central, Maintz, L., et al
Retatrutide (research grade), also designated LY3437943, is a long-acting synthetic peptide engineered to co-engage three distinct G-protein-coupled receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)
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