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This greatly improves its ability to remain intact in the gut and allows a greater concentration to be absorbed into the bloodstream where it can take effect
These effects could be particularly valuable in treating conditions such as inflammatory bowel disease, where mucosal healing is a critical therapeutic endpoint
In addition, these metabolic effects do not appear to be related to their diuretic action or intended pharmacological targets, raising concerns about the long-term metabolic impact of specific diuretics, particularly in vulnerable populations, including those with metabolic syndrome
When ER zinc balance is disrupted, ER stress pathways become activated, triggering the unfolded protein response (UPR) 121,122
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