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doi: 10.1038/ncomms9917 30 WangZRZhangXLLiWGSuQHuangZYZhangXYet al
A multi-species model study, this time using the GLP-1RA liraglutide, did not demonstrate adverse pancreatic effects, including cell proliferation 29
Mechanism of inflammation and neuroendocrine dysregulation in obesity
However, case reports and pharmacokinetic data from 20242025 suggest breakthrough pregnancies occur in a small but real percentage of women combining these therapies
By inhibiting autophagy and inducing mitochondrial ROS, TMAO activates NLRP3 inflammasome, leading to the release and pyroptosis of IL-1/IL-18 dependent on caspase-1 in colon epithelium, which is a hallmark of IBD severity
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