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Tips for managing constipation A more sluggish GI system can lead to constipation, says Rao
It comes in two FDA-approved forms, both weekly injections: Mounjaro: type 2 diabetes (2.5 to 15 mg) Zepbound: obesity (2.5 to 15 mg) and moderate-to-severe obstructive sleep apnea in adults with obesity (approved December 2024) No oral tirzepatide exists as of April 2026
The dose titration schedule starts at 2.5 mg and increases every 4 weeks through 5 mg, 7.5 mg, 10mg, and 12.5 mg before reaching the maintenance dose of 15 mg at around week 20
Supplemental doses usually range from 0.5 to 2 g/day (133)
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