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The decision to escalate, hold, or reduce should always involve the prescribing clinician

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In one large clinical trial, patients on 2.4 mg of Wegovy each week who received individualized lifestyle counseling sessions, followed a low-calorie diet, and increased physical activity lost an average of almost 15% of their body weight after 68 weeks

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The findings of another prospective study (the Hordaland Health Study) that followed 7,045 healthy adults (ages, 47-49 years and 71-74 years) suggested that high choline and low betaine plasma concentrations were associated with an unfavorable cardiovascular risk profile (51)

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