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GLP-1related shedding typically begins two to three months after a significant body change, such as rapid weight loss or a dose adjustment
Some peptides are given by injection because they may not be absorbed well through the digestive tract
10.1073/pnas.261708898
Long-term safety data extends to four or more years for semaglutide and continues to accumulate for tirzepatide
In the 68-week STEP 1 trial summarised in Wegovys Australian product information, the average weight change was -14.9% with Wegovy versus -2.4% with placebo, and almost 48% of patients achieved at least 15% weight loss
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