ada standards of care 2025 obesity pharmacotherapy glp-1 10 Highlights the of The evolving landscape of obesity

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Long-term effects of chronic GHS-R1a activation on cancer risk (GH and IGF-1 are growth factors), glucose metabolism (GH antagonizes insulin), and joint health are unknown

3 Adverse effects 3.1 Gastrointestinal effects Despite its widespread availability and affordability, metformin is associated with gastrointestinal side effects, including nausea, vomiting, diarrhea, and bloating, affecting around 20% of patients (Sanchez-Rangel and Inzucchi, 2017

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No bowel movement for more than a week despite using over-the-counter remedies