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The science is biologically plausible, the early findings are encouraging, and the available safety data appears favorable, but its important to be transparent about what we know, what we dont know, and where the evidence still needs to mature

People with certain health conditions, like a history of pancreatitis, gallbladder disease, or severe kidney problems, may need to avoid these medications

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tirzepatide adds GIP (dual agonist) and retatrutide adds glucagon (triple agonist), with generally larger weight effects in trials but different tolerability profiles

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