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doi: 10.3389/fmicb.2021.688137 553 PohjavuoriEViljanenMKorpelaRKuitunenMTiittanenMVaaralaOet al

Recently, there is a theory explaining how NRF2 is stabilized under stress conditions, called the two-site substrate hinge and latch model. It is known that each of the two dimeric KEAP1 molecules will bind NRF2 separately through their respective Kelch repeat domain to either the ETGE or DLG motifs in NRF2