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Direct medication costs (approximate, 2026): Brand-name Wegovy: $1,400 per month ($16,800 per year) Compounded semaglutide: $250 to $400 per month ($3,000 to $4,800 per year) With insurance coverage: $25 to $50 per month ($300 to $600 per year) Indirect costs of regain: Weight regain after discontinuation carries health costs that are harder to quantify but real: Increased risk of type 2 diabetes (if weight returns to pre-treatment level, diabetes risk returns to baseline) Increased cardiovascular risk (weight loss on GLP-1 agonists reduces cardiovascular events
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United Kingdom Prospective Diabetes Study (UKPDS) Group
In one landmark trial, the STEP 1 study, participants receiving Semaglutide experienced an average weight loss of around 15% over 68 weeks
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