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Still, Gilead is preparing for Biktarvys future loss of exclusivity (2033), with plans to launch nine new HIV drugs, including the long-acting injectable Lenacapavirapproved in 2022 and named a 2024 breakthrough by *Science*

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By activating both pathways at the same time, tirzepatide may produce broader effects on appetite and metabolic regulation than a single-pathway approach

Pancreatic stellate cells (PSCs) are essential components of the tumor stroma that interact dynamically with PCCs to create a signaling network centered around extracellular matrix (ECM) proteins, which collectively promote the progression of PDAC

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