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This is the central unresolved question in the field and it is not answerable from most published work, because the controls needed to answer it are frequently absent

People with obesity have been shown to be at an increased risk of other serious weight-related comorbidities such as certain types of cancer, heart disease, strokes, hypertension (high blood pressure), metabolic disorders, and an increased risk of developing diabetes

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Metabolomics study of urine in patients with hepatocellular carcinoma (Tianjin: Tianjin Medical University)

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