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Necroptosis has been shown to be strongly associated with vitiligo, as melanocytes from perilesional skin affected by vitiligo were significant for necroptosis markers, such as phosphorylated RIP3 and a phosphorylated mixed-lineage kinase-like domain

Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation

With the deepening understanding of the oral and Gl microbiome and microbiological technology development, an increasing number of studies are exploring the potential of probiotics, prebiotics, and engineered probiotics in the management of these diseases