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Common mild observations in studies include transient facial flushing and headache

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Indeed, RYGB, which causes marked gastrointestinal distension due to how it forces food passage through the reconfigured gastrointestinal tract, leads to the same central pattern of neuronal activation as activating GLP-1R-expressing and OXR-expressing vagal afferents in mice [31, 36, 37], while vagotomy partially prevents the appetite suppression and weight loss caused by RYGB in rats [38]

[20] As a pharmacist, I can appreciate why such a profile has made this drug the next blockbuster