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IR induced metabolic disturbances lead to degradation of brain function, and prolonged uncontrolled high blood glucose levels adversely affect a variety of metabolic pathways such as oxidative stress, formation of advanced glycosylation end products (AGEs), and protein kinase C activation, while metabolic disturbances inducing cerebral microvascular damage affect the extent of cognitive impairment (1, 7)

L.KeelyS.HugenholtzP.et al

While Ortega described the universal feeling women have about food, hunger, and an obsession to be smaller, be less, in my experience to be fat is to do nothing right ever: lose weight but not like that, and dont do it around my boyfriend because I can tell you want to steal him, and for gods sake, take everyone elses trauma and eating disorder into account before you do lose weight

Loperamide (Imodium) may be used occasionally for acute episodes without fever or bloody stools, but should not be used for more than two days without medical consultation

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