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For Mounjaro, across the SURPASS trials in type 2 diabetes, cholelithiasis was reported in 0.6% of tirzepatide-treated patients compared to 0% in the placebo group
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We conclude that a single nucleotide substitution was sufficient to switch the repair mechanism, relative to the substate with symmetric G:T mispairs: the ordered, semi-conservative path to repair is now dominant (model 2 favored 18:1 over model 1)
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