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Tachyphylaxis and Duration of Effects A key feature of gastric effects associated with GLP-1 RA is the phenomenon of tachyphylaxis, where the gastric emptying effects diminish over time with continuous exposure lasting 8 to 24 h [18]
Millions of people are losing significant weight on these drugs, and the clinical data is impressive: trials like STEP 1 showed participants losing roughly 15% of total body weight over 68 weeks
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