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However, after initial sensitivity, many patients develop resistance to treatment 42,43

Petridou AI, Zagora ET, Petridis P, et al

J Biol Chem 276:2193821942 Peskin AV, Winterbourn CC (2006) Taurine chloramine is more selective than hypochlorous acid at targeting critical cysteines and inactivating creatine kinase and glyceraldehyde-3-phosphate dehydrogenase

We speculate that PUFAs and iron are specifically absorbed in the small intestine 32,33,44 , which could be one explanation for small intestinal disease localization and a requirement for GPX4 activity in the small intestine

Arch Pediatr Adolesc Med 161:35661, PMID: 17404132 Rezaei Z, Saadat I, Saadat M (2012) Association between three genetic polymorphisms of glutathione S -transferase Z1 (GSTZ1) and susceptibility to bipolar disorder