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When the B-series compounds were evaluated in the fura-2 assay using STC-1 cells, they were established to be especially weak Ca 2+ elevating agents such that a test concentration of 10 M was necessary to detect any increase of [Ca 2+ ] i (data not shown)

Acknowledgments The authors thank Regi Mathew for providing patient data and Jon Hernandez for coordinating the transportation of samples from patients rooms to research laboratories

However, no studies have shown that it restricts the enzyme tyrosinase required for melanin formation

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Across the nine-month follow-up period, 60 percent of patients treated with mavacamten monotherapy improved by at least one Co-author Garima Arora, M.D., co-director of the UAB Cardiogenomics Clinic, emphasized the practice-changing implications