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The prevalence of these conditions range between 2 and 6% of population [12]
Patent filings have concentrated on sequence optimization, receptor balance, and dosing regimens [5, 6], while scientific reviews increasingly position these compounds as the next frontier beyond single-target GLP-1 therapy [1, 2]
For severe hypertriglyceridemia (500 mg/dL), fibrates or prescription omega-3 fatty acids (icosapent ethyl) remain first-line to prevent pancreatitis, though GLP-1 therapy may provide additional benefit in appropriate patients
treatment -4.22 mIU/ml (5.42)
McGuireDKVande Werf FArmstrongPWStandlEKoglinJGreenJBet al
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