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most patients lose 510% of baseline weight Months 612: Peak weight loss typically occurs, with some patients losing 1015% or more of initial body weight in clinical trials, particularly on higher-efficacy agents like semaglutide 2
Chiedza Kaitano, PhD Vice President, Global Program Head, Obesity September 17, 2025 Over the last few years, it has become clear we are in a new era for treating obesity, a complex, multifaceted chronic disease affecting over a billion people globally
The dose of retatrutide matters enormously here because higher doses mean more glucagon receptor activation and proportionally greater heart rate effects
T1D/T2D, type 1/2 diabetes
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