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In both male and female GHRKO mice, disruption of the GH/IGF-1 axis from birth results in mice that are remarkably long lived, but temporal disruption of this pathway in young adults (aGHRKO mice) improves lifespan only in females 17 , an observation which is consistent with the beneficial effects of targeting IGF-1R signaling post-development on female healthspan and aging in this study
Methods 4 , 107108 (2007)
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Ipamorelin stimulates endogenous GH secretion from somatotropes by activating GHS-R1a, which maintains the physiological pulsatile release pattern
& Duhan, A
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