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Cell-based assays use both heterologous expression in CHO-K1 and HEK293 cells and pituitary-derived cell lines retaining endogenous GHRH-R
These effects could lead to suppressing cyclin D1, re-expressing silenced tumour suppressor genes, inhibiting inflammation mediated by NF-B, or downregulating metastatic markers like MMP-2 and MMP-9
PMID: 36402502
The TB-500 fragment retains the actin-binding domain considered responsible for these wound healing properties
7d) and expression of NF-B target genes, including c-FLP , c-IAP , and MnSOD (Fig
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