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A controversy circulated about the TMAO metabolite (associated with very high doses), but recent studies indicate that this effect is negligible at standard doses

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"Dentro dos dados da literatura apresentados at o momento, aparenta ser o medicamento mais potente que ns temos tanto para o controle da glicose, como para a reduo do peso nesses pacientes", comenta Rodrigo Lamounier, endocrinologista e diretor da Associao Brasileira para o Estudo da Obesidade e da Sndrome Metablica (Abeso)

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However, initial signs of weight reduction can be observed within the first few weeks of treatment