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Individuals who were 21 years of age or older, were at moderate risk for cardiovascular disease, and had a newly filled prescription for SGLT2i, GLP1RA, DPP4i, or SU between January 1, 2014, and December 31, 2021 were considered for the analysis

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Specifically, rodent studies showed an increased incidence of thyroid C-cell tumours (medullary thyroid carcinoma) when exposed to GLP-1 receptor agonists at doses significantly higher than those used therapeutically in humans

General peptide injection guidance applies as well, since the subcutaneous technique is consistent across most injectable peptides