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Ethics statement The animal study was reviewed and approved by the Laboratory Animal Welfare and Ethics Committee of Fourth Military Medical University
while brain endothelial and nerve cells, red blood cells, lymphocytes - appear incapable of absorbing GSH as the intact tripeptide) L-methionine Is an essential amino acid It must first be converted to cysteine This convertion is inactive in neonates and in certain adults, such as patients with liver disease The "activated" methionine metabolite known as SAM (S-adenosyl methionine) is effective in raising red cell GSH and hepatic GSH when given orally at 1600 mg per day L-methionine L-methionine intake is 13 mg per kg or about 0.75 gram daily for adults During methionine supplementation, intake B6 and folic acid should also be included Excessive methionine intake, together with inadequate intake of folic acid, vitamin B6, and vitamin B12, can increase the conversion of methionine to homocysteine Homocysteine is a potentially harmful blood fat that has been linked to atherosclerosis Table 1
They were counseled regarding the risks, benefits, and potential complications of therapy and their informed written consent was obtained
