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Cillo, A
This foundational in vivo evidence has driven an expanding research programme using FOXO4-DRI as a molecular tool across multiple tissues and disease contexts
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Three pilot studies with very small sample sizes, a Phase II trial whose results remain unpublished, and a regulatory record that reflects the FDA's own assessment that sufficient human safety data do not exist that is the complete ledger as of 2025
Eren-Yazicioglu et al., 2021
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