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Amy Rothberg indicates a potential misalignment between clinical trial parameters and real-world use, pointing out that mental health conditions were not represented in Ozempic's trials, possibly overlooking related side effects
As an alternative approach to improve in vivo stability of the fusion molecule, we then engineered a disulphide bridge into the exendin-4 peptide moiety (Ab#2_DSB#1) as this has been shown to improve in vitro and in vivo stability of both GLP-1 and exendin-4 analogue peptides 36
Needed a reset, met with Luke and very happy to revisit in person today
Berberine, dietary fibre, and omega-3 fatty acids have preliminary evidence for modest effects on GLP-1 secretion, but human studies are limited
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