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Endogenous GLP-1 has several functions, including triggering insulin release from the pancreas, as well as decreasing appetite and digestion, and this drug class mimics the GLP-1 hormone
PF-06882961 agonist activity was assessed at both the cAMP and Arr pathways and compared to the marketed GLP-1R agonists exenatide and liraglutide
The intranasal spray formulation provides additional scientific value by allowing laboratories to investigate formulation stability, spray consistency, peptide integrity, physicochemical characteristics, analytical reproducibility, and intranasal delivery system performance
In total, 36 studies were included in the qualitative analysis and 24 in the meta-analyses
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