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& Croce, C
Drug costs would total nearly $66 billion, with about $18 billion saved through reduced hospitalizations and chronic disease care
Lets translate this into clinical reality Absolute risk reduction 3.7% over 3 years NNT 27 So yes this is clinically meaningful But heres the uncomfortable truth: This benefit is conditional
For example, if you started at 200 pounds, an initial loss of 1-2% of your body weight is a reasonable expectation
Over-the-counter options like orlistat (Alli) and supplements like berberine never face prescription or supply barriers
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