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Stopping exercise-induced muscle damage: A huge meta-analysis of 20 different studies showed that creatine monohydrate lowered levels of muscle damage after acute training.[ref] Improving muscle mass in weight training: Quite a few clinical trials show that creatine supplements can help to improve muscle mass while decreasing damage.[ref][ref][ref] Mood disorders: Clinical trials show that creatine may help with depression caused by a lack of brain energy or oxidative stress.[ref] In people with bipolar disorder, 6g/day of creatine was trialed against a placebo

R 2 = 0.16, p = 0.0049 under 9999 permutations, Fig