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Existing findings indicate that the protective mechanism is mainly attributed to the GLP-1 signaling pathway, which involves cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) and cAMP response element-binding protein (CREB)

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The Functional Bottom Line In middle-aged obese patients treated with semaglutide for 12 weeks, muscle strength was completely preserved despite a reduction in muscle size