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A significant presence of a GSTP1-1 allelic variant (the GSTP1*C allelic variant) was found in late-onset AD patients 52

Statements Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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DLin-MC3-DMA was integral to the development of the first FDA-approved siRNA drug, Onpattro, and has been proven effective for mRNA delivery in vivo

Finally, we discuss emerging therapies under investigation, particularly those focused on neurogenesis and brain matter recovery, which hold promise for restoring metabolic homeostasis and combating the long-term effects of PACS