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In IFN group, 72 (7.8%) patients had ALT elevation above 3 ULN, significantly higher than that in Nuc group (15[1.5%], p 20 IU/mL at baseline

10.1021/acsptsci.4c00586 136 SrinivasanE.ChandrasekharG.ChandrasekarP.AnbarasuK.VickramA

To address this, some companies use stabilized forms like Na-R-ALA (sodium-R-alpha-lipoate), which binds R-ALA to sodium to help resist degradation

There are a few contraindications: People with family history of medullary thyroid cancer or a rare genetic syndrome called MEN2 should not take GLP-1s, for instance