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65,66 Inflammation and long-term ulceration of the colonic mucosa caused by UC may lead to abnormal proliferation and differentiation of colonic mucosal cells, thereby increasing the risk of colorectal cancer

Real-world evidence: Across observational studies, approximately 2050% of patients discontinue GLP-1 therapy within the first year, most commonly because of gastrointestinal adverse events, medication cost, insurance barriers, or drug shortages

Step 3: Start Tirzepatide at 2.5mg, Regardless of Prior Semaglutide Dose There is no validated dose equivalence between semaglutide and tirzepatide