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Increased FAO may be an adaptive response in patients with NAFLD attempting to reduce the lipid overload and lipotoxicity, but also produces ROS and excessive FAO may overwhelm the capacity of the anti-oxidant defense system and induce oxidative stress

& Durvasula, R

Allergic Reaction to Semaglutide Individuals who have experienced a serious allergic reaction to semaglutide, the active ingredient in Wegovy, are considered unsuitable candidates for Wegovy

Those with a long half-life (weekly exenatide, efpeglenatide, liraglutide, semaglutide, albiglutide and dulaglutide) produce a sustained activation of rGLP1, resulting in a greater reduction in HbA1c, basal glycemia and body weight and would have fewer gastrointestinal side effects

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