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For instance, SGLT2 inhibitors may be added if first-line therapies such as diet and lifestyle changes plus metformin are insufficient
FOXO transcription factors as mediators of stress adaptation
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Other studies, none of which were RCTs, reported variable results
Heightened systemic inflammatory states appear to worsen COVID-19 outcomes by initiating a counter-regulatory response, which includes the upregulation of levels of the ACE2 receptor and its associated peptidases 11
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