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There may also have been problems with sample storage over long periods, especially for plasma homocysteine and vitamin analyses

The PDUFA date (the FDA's target decision deadline) will likely be set in Q2 2026 after the NDA is accepted for filing

At the starting 0.25 mg/week dose, effects are usually mild

The relatively slow uptake may support stable plasma levels and reduce fluctuations in exposure, which is relevant for compounds intended to act over extended periods

Other studies also revealed that the several extracts of Curculigo latifolia possesses anti-oxidant and tyrosinase inhibitory activities and also it has been reported that Curculigo latifolia could be a possible component for skin whitening agent [166]