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Type 1 is the enzyme variant primarily responsible for converting testosterone to DHT in hair-damaging locations, and this inhibition occurs with greater specificity for the hair-relevant type 1 than the prostate-relevant type 2
A total of 200 M hydrogen peroxide (H 2 O 2 ) significantly induced cytotoxicity in HeLa cells, while H 2 O 2 up to 300 M did not induce cytotoxicity in HepG2 cells, further demonstrating the strong resistance of HepG2 cells to ROS
Monitoring : After initiating treatment, regular monitoring is vital
Peptide Sciences Applications in Research As a molecular probe to study NNMT function, regulation, and downstream metabolic pathways To investigate metabolic flux , methylation dynamics, NAD salvage, and related bioenergetic phenomena In cellular assays , to test effects of NNMT inhibition on gene expression, metabolite profiling, or metabolic phenotypes In animal / ex vivo experiments for mechanistic elucidation of metabolic regulation (e.g
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