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In the research context for separating the effect on central satiety vs peripheral lipolysis
They measured subjective sleep quality more than objective sleep quality They subjectively estimated tiredness Sleep structure was not fully characterized by polysomnography in all studies Data analysis suggested some observed changes were due to issues with the placebo group What is promising about these findings is that statistically significant effects were found in such small sample sizes
Zemdegs J, Quesseveur G, Jarriault D et al (2016) High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice
What matters more is maintaining a consistent 7-day interval between doses
Tirzepatide independently causes a modest heart rate increase, averaging 2-4 beats per minute in the SURMOUNT clinical trials
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